Hepatic Sinusoidal Obstruction Syndrome Caused by Herbal Medicine: CT and MRI Features.
10.3348/kjr.2014.15.2.218
- Author:
Hua ZHOU
1
;
Yi Xiang J WANG
;
Hai Yan LOU
;
Xiao Jun XU
;
Min Ming ZHANG
Author Information
1. Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Original Article
- Keywords:
Hepatic sinusoidal obstruction syndrome;
Herbal medicine;
Pyrrolizidine alkaloid;
Computed tomography;
Magnetic resonance imaging
- MeSH:
Adult;
Aged;
Ascites/diagnosis;
Asteraceae/chemistry;
Cholecystography;
Female;
Gallbladder/pathology;
Hepatic Veins/pathology/radiography;
Hepatic Veno-Occlusive Disease/chemically induced/*diagnosis;
Hepatomegaly/diagnosis;
Humans;
*Magnetic Resonance Imaging;
Male;
Middle Aged;
Phytotherapy/*adverse effects;
Pyrrolizidine Alkaloids/adverse effects;
Severity of Illness Index;
*Tomography, X-Ray Computed;
Young Adult
- From:Korean Journal of Radiology
2014;15(2):218-225
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To describe the CT and MRI features of hepatic sinusoidal obstruction syndrome (HSOS) caused by herbal medicine Gynura segetum. MATERIALS AND METHODS: The CT and MRI features of 16 consecutive Gynura segetum induced HSOS cases (12 men, 4 women) were analyzed. Eight patients had CT; three patients had MRI, and the remaining five patients had both CT and MRI examinations. Based on their clinical presentations and outcomes, the patients were classified into three categories: mild, moderate, and severe. The severity of the disease was also evaluated radiologically based on the abnormal hepatic patchy enhancement in post-contrast CT or MRI images. RESULTS: Ascites, patchy liver enhancement, and main right hepatic vein narrowing or occlusion were present in all 16 cases. Hepatomegaly and gallbladder wall thickening were present in 14 cases (87.5%, 14/16). Periportal high intensity on T2-weighted images was present in 6 cases (75%, 6/8). Normal liver parenchymal enhancement surrounding the main hepatic vein forming a clover-like sign was observed in 4 cases (25%, 4/16). The extent of patchy liver enhancement was statistically associated with clinical severity classification (kappa = 0.565). CONCLUSION: Ascites, patchy liver enhancement, and the main hepatic veins narrowing were the most frequent signs of herbal medicine induced HSOS. The grade of abnormal patchy liver enhancement was associated with the clinical severity.
