Comparison of Mortality and Morbidity in Multiple versus Singleton Very Low Birth Weight Infants in A Neonatal Intensive Care Unit.
10.3346/jkms.2003.18.6.779
- Author:
Kye Hyang LEE
1
;
Soo Jung HWANG
;
Sung Hye KIM
;
Soo Hyun LEE
;
Dong Kil YU
;
Jong Hee HWANG
;
Chang Won CHOI
;
Jae Won SHIM
;
Yun Sil CHANG
;
Won Soon PARK
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wspark@smc.samsung.co.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Multiple Birth Offspring;
Infant;
Very Low Birth Weight;
Mortality;
Morbidity
- MeSH:
Birth Weight;
Comparative Study;
Female;
Gestational Age;
Human;
Infant;
*Infant Mortality;
Infant, Newborn;
*Infant, Very Low Birth Weight;
*Intensive Care Units, Neonatal;
Korea;
Maternal Age;
Morbidity;
Pregnancy;
*Pregnancy Outcome;
*Pregnancy, Multiple;
Retrospective Studies
- From:Journal of Korean Medical Science
2003;18(6):779-782
- CountryRepublic of Korea
- Language:English
-
Abstract:
Multiple births in Korea have been increased recently as a consequence of increased infertility due to advancing maternal age at first birth, and increased use of assisted reproductive technology. Multiples suffer higher mortality and morbidity than singletons. However, it is not clear whether preterm multiple very low birth weight infants (VLBWI) suffer higher mortality and morbidity than comparable singletons. We evaluated 266 singleton and 113 multiple VLBWI to determine whether mortality and morbidity in multiple VLBWI were higher than those in comparable singletons. The rate of in vitro ertilization and cesarean section were significantly higher in multiples than singletons. The total and the adjusted mortality with gestational age and birth weight were not significantly different between the two groups. Maternal age and the incidence of respiratory distress syndrome, patent ductus arteriosus, bronchopulmonary dysplasia, intracranial hemorrhage (grade> or=3), cystic periventricular leukomalacia, and retinopathy of prematurity (stage> or=3) were not significantly different between the two groups, and the incidence of abnormal brainstem auditory evoked potential was higher among the singletons. These results suggest that multiple VLBWI do not suffer higher mortality or morbidity than comparable singletons.
