Combined Effect of Low-dose Nitric Oxide Gas Inhalation with Partial Liquid Ventilation on Hemodynamics, Pulmonary Function, and Gas Exchange in Acute Lung Injury of Newborn Piglets.
10.3346/jkms.2003.18.6.813
- Author:
Chang Won CHOI
1
;
Jong Hee HWANG
;
Yun Sil CHANG
;
Won Soon PARK
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wspark@smc.samsung.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Liquid Ventilation;
Fluorocarbons;
Nitric Oxide
- MeSH:
Administration, Inhalation;
Animals;
Animals, Newborn;
Fluorocarbons/metabolism;
Hemodynamic Processes;
*Liquid Ventilation;
Nitric Oxide/administration & dosage/*metabolism;
Plasma Substitutes/metabolism;
Pulmonary Gas Exchange/*physiology;
Random Allocation;
*Respiratory Distress Syndrome, Adult;
Respiratory Mechanics;
*Respiratory Physiology;
Support, Non-U.S. Gov't;
Swine
- From:Journal of Korean Medical Science
2003;18(6):813-820
- CountryRepublic of Korea
- Language:English
-
Abstract:
We conducted a randomized animal study to determine whether there is a cumulative effect on hemodynamics, pulmonary function, and gas exchange when low dose nitric oxide (NO) is added to partial liquid ventilation (PLV) in acute lung injury. ighteen newborn piglets were saline-lavaged repeatedly, and randomly divided into two groups: PLV with perfluorocarbon group (n=8) and lavage only (control) group (n=10). Perfluorodecalin (30 mL/kg) was instilled into the endotracheal tube for 30 min, followed by 5-10 mL/kg/hr. Fifteen minutes after the completion of perfluorodecalin dosing, NO (10 ppm) was added to the inspiratory gas in an "on/off" manner. Perfluorodecalin instillation produced a significant improvement in gas exchange, pulmonary mechanics, shunt, and pulmonary arterial pressure (PAP). The addition of NO produced a further significant improvement in PaO2 and PAP. The "on/off" response to NO was seen apparently in PAP, PaO2, dynamic compliance, and shunt. All the variables in control group were remained at near the after-lavage levels without significant improvements until the end of the experiment. We concluded that NO might have a cumulative effect on gas exchange when combined with PLV, and this might be attributable to deceased PAP and V/Q mismatching.
