Expression of E-cadherin according to the Presence of High Risk Prognostic Factors, Clinical Stages and Pathologic Types in Cervical Cancer Patients Treated by Radical Hysterectomy.
- Author:
Min Heui YI
;
Eui Jong HUR
;
Jin Wan PARK
;
Min Chul LEE
;
Won Ki LEE
- Publication Type:Original Article
- Keywords:
E-cadherin;
Cervical cancer;
Prognostic factors
- MeSH:
Cadherins*;
Gynecology;
Humans;
Hysterectomy*;
Neoplasm Metastasis;
Obstetrics;
Risk Factors;
Uterine Cervical Neoplasms*
- From:Korean Journal of Obstetrics and Gynecology
2000;43(6):974-979
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To analyze the relationship between the degree of expression of E-cadherin and presence of high risk prognostic factors (lymph node metastasis or parametrium involvement), clinical stages and pathologic types in invasive cervical cancer. METHODS: An immunohistochemical technique has been applied to formalin-fixed, paraffin- embedded samples from 20 radical hysterectomy without risk factors and 16 radical hysterectomy with risk factors. The degree of expressions of E-cadherin immunostaining was compared with the International Federation of Gynecology and Obstetrics (FIGO) stage, presence of high risk prognostic factors, and pathologic types. RESULTS: The difference of the degree of expression of E-cadherin was not statistically significant between high-risk group (lymph node metastasis or parametrium invasion) and non-risk group. The difference of the degree of expression of E-cadherin was not statistically significant according to clinical stages and variable pathologic types either. CONCLUSIONS: These results suggest that the degree of the expression of E-cadherin has no relationship with known high risk prognostic factors, clinical stages and pathologic types in invasive cervical cancer.
