Juvenile Pernicious Anemia in Sisters.
- Author:
Duk Jin YUN
1
;
Hyun LEE
;
Goeng Pil CHUN
;
Ki Young LEE
Author Information
- Publication Type:Original Article
- MeSH: Anemia, Pernicious/*genetics; Child; Female; Human; Vitamin B 12/*therapeutic use
- From:Yonsei Medical Journal 1967;8(1):71-76
- CountryRepublic of Korea
- Language:English
- Abstract: Two cases of juvenile pernicious anemia in Korean sisters have been followed for 4 years since 7 years and 4 years of age respectively. The symptoms and signs were pale facies, general malaise, sore tongue, anorexia, frequent febrile episodes, macrocytic hyperchromic anemia, thrombocytopenia, multilobulated leucocytes with more than 6 lobules and megaloblastic proliferation in bone marrow aspiration. Dramatic hematological response to the parenteral administration of vitamin B12 with a significantly increased excretion rate of vitamin Bl2 by Schilling test as shown by an increase from 0 to 11.6% in elder sister and from 0 to 5.6% in younger sister with the addition of commercial intrinsic factor were demonstrated. These findings are compatible with the characteristics of juvenile pernicious anemia resulting from defect of Cast1e's intrinsic factor.
