Dosimetry and Medical Internal Radiation Dose of Re-188-DTPA for Endovascular Balloon Brachytherapy Against Restenosis after Coronary Angioplasty.
- Author:
Myung Chul LEE
;
June Key CHUNG
;
Dong Soo LEE
;
Jae Min JEONG
;
Jin LEE
;
Seung Ae SHIN
- Publication Type:Original Article
- Keywords:
Re-188-DTPA;
dosimetry;
MIRD;
restenosis
- MeSH:
Angioplasty*;
Animals;
Brachytherapy*;
Coronary Vessels;
Dogs;
Kidney;
Radiometry;
Rupture;
Whole-Body Irradiation
- From:Korean Journal of Nuclear Medicine
1999;33(2):163-171
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Liquid beta emitter filled in angioplasty balloon could be used to perform endovascular balloon brachytherapy to prevent coronary artery restenosis. We investigated the dosimetry for Re-188-DTPA liquid-filled balloon and medical internal radiation dosimetry in case of balloon leakage. MATERIALS AND METHODS: We estimated radiation dose from an angioplasty balloon (20 mm lengfh, 3 mm diameter cylinder) to the adjacent vessel wall using Monte Carlo EGS4 code. We obtained time-activity curves of kidneys in normal dog and calculated Tmax, T1/2. Using MIRDOSE3 program, we estimated absorbed doses to the major organs (kidneys, bladder) and the whole body when we assumed that balloon leaked all the isotope contained. RESULTS: The radiation dose was 17.5 Gy at the balloon surface when we applied 3,700 MBq/ml of Re-188 for 100 seconds. Fifty percent of the energy deposited within 1 mm from the balloon surface. The estimated internal dose to the whole body was 0.005 mGy/MBq and 18.5 mGy for the spillage of 3,700 MBq of Re-188. CONCLUSION: We suggest that Re-188-DTPA can be used for endovascular balloon brachytherapy to inhibit coronary artery restenosis after angioplasty with tolerable whole body radiation dose in case of balloon rupture.
