Induction of Radiation Adaptive Response in Lymphocytes of patients Undergoing Bone Scintigraphy.
- Author:
Hee Seung BOM
;
Jung Jun MIN
- Publication Type:Original Article
- Keywords:
Tc-99m methylene diphosphonate;
Bone scintigraphy;
Chromosomal aberration;
Radiation
- MeSH:
Chromosome Aberrations;
Cytogenetics;
Female;
Gamma Rays;
Humans;
Lymphocytes*;
Male;
Radionuclide Imaging*;
Technetium Tc 99m Medronate
- From:Korean Journal of Nuclear Medicine
1999;33(2):172-177
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to ascertain whether radiation adaptive response could be induced by Tc-99m-methylene diphosphonate (Tc-99m-MDP) in peripheral lymphocytes of patients undergoing bone scintigraphy. MATERIALS AND METHODS: Lymphocytes from 22 patients (6 males, 16 females, mean age 50+/-14 years) were collected before and after bone scintigraphy using 740 MBq Tc-99m-MDP. Lymphocytes from 10 controls (6 males, 4 females, mean age 43+/-7 years) were also collected. They were exposed challenge dose of 2 Gy gamma rays using a cell irradiator Number of ring-form and dicentric chromosomal per 600 cells (chromosomal aberrations) was counted under the light microscope. RESULTS: Chromosomal aberrations in patients before bone scintigraphy (385.1+/-30.5) was not different from that of controls (367.8+/-36.6). However, chromosomal aberrations in patients after bone scintigraphy was significantly decreased 192.6+/-22.1 (p=0.0001). CONCLUSION: Low dose gamma-irradiation by Tc-99m-MDP used for bone scintigraphy induces a cytogenetic adaptive response in peripheral lymphocytes.
