Assessment of Atrophy of Human Epidermis Caused by Various Corticosteroids Using Chamber Occlusion and Histometry.
- Author:
Young Il CHUN
;
Joon Mo YANG
;
Myoung Soo SUH
;
Hee Chul EUN
;
Yoo Shin LEE
- Publication Type:Original Article
- Keywords:
Epidermal thinning;
Corticosteroids;
Histometry;
Chamber Occlusion
- MeSH:
Adrenal Cortex Hormones*;
Atrophy*;
Capillaries;
Dermis;
Diethylpropion;
Epidermis*;
Fluocinolone Acetonide;
Fluocinonide;
Humans*;
Hydrocortisone;
Ointments
- From:Korean Journal of Dermatology
1986;24(5):579-585
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The aim of this stud y was to compare the epidermal thinning properties of four corticosteroid ointments applied under occlusion, using histology and histometry. The results were surnmerized as follows: 1.The stratum corneurn was dramatically thinned, appearing as a wispy layer of horny cells as apposed to the norrnal basket-weave configuration. this effect was prominent at sites treated with clobestasol propionate, fluocinonide, and fluocinolone acetonide. 2. With the histometry, visible epidermal thickness wa.s markedly reduced. This effect w is prominent in the following ascending order: fluocinolone acetonide, fluocienonide, clobestasol-17-propionate. Hydrocortisone was the least atrophogenic. 3. Clohestasol-17-propionate and fluocinonide caused significant flattening of dermo-epidermal junction, Fluocinolone acetonide and hydrocortisone caused less pronounced cbanges. 4. Marked capillary dilation af papilly dermis is caused by clobestasol-17-propionate, fluocinonide and fluocinolone acetonide.
