Epidermal Changes with Ultraviolet Irradiation and PUVA Treatment in the Black Mouse.
- Author:
Kyung Won HAN
;
Hae Ki HAN
;
Ki Bum MYUNG
;
Hong Il KOOK
- Publication Type:Original Article
- Keywords:
UV light;
PUVA;
Epidermal change
- MeSH:
Animals;
Atrophy;
Dihydroxyphenylalanine;
Edema;
Epidermis;
Hyperplasia;
Intermediate Filaments;
Keratinocytes;
Melanocytes;
Methoxsalen;
Mice*;
Photosensitivity Disorders;
Ultraviolet Rays;
Vacuoles
- From:Korean Journal of Dermatology
1986;24(5):586-593
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The pretent study was performed to study the epiderrnal changes of ultraviolet irradiation and PUVA treatment in the black mice. The following results were obtained: 1) The histologic changes of the epidermis, number of DOPA positive melanocytes and ultrastructural changes of keratinocytes due to UVB and PUVA were rnore prominent than those of UVA irradiation. 2) The histological changes after 8-MOP photosensitization closely mirnic those of UVR irradiation, and constant, finding was hyperkeratosis. 3) Early histological change after UVL irradiation & IUVA treatment was appearance of dytkeratotic cells. 4) Pro]onged exposure to UVB & PUVA resulted in transient epidermal hyperplasia, and epidermal atrophy occurred 3 weeks after PUVA treatment. 5) Early electron microscopic changes was perinuclear edema, juxtanuclear vacuoles and clumping of tonofilament.
