Treatment of Gonorrhea with Antibiotic Combination Regimens - Kanamycin plus Benzyl Penicillin G / Probenecid versus Kanamycin plus Trimethoprim-Sulfamethoxazole.
- Author:
Kyu Uang WHANG
;
Jae Hong KIM
;
Joong Hwan KIM
- Publication Type:Original Article
- Keywords:
Gonorrheal urethritis;
Combination treatment;
Trimethoprim - sulfamethoxazole
- MeSH:
Gonorrhea*;
Humans;
Kanamycin*;
Male;
Penicillin G*;
Penicillins*;
Probenecid*;
Public Health;
Trimethoprim, Sulfamethoxazole Drug Combination*;
Urethritis
- From:Korean Journal of Dermatology
1986;24(5):623-630
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
From August to November 1985 244 bacteriologically proven male uncomplirated goncicoccal urethritis patients at the VD clinic of Choong-Ku Public Health Center form August to November 1985 were divided into group A and group B according to a random number sheet. In group A, treated with kanamycin 2.Ogm, im plus benzyl penicillin-G 5 mega units, im plus probenecid, 1.Ogm, PO; 112 of 121 patients were followed and 10 patients (8.9%) failed to be recovered. In group B, treated with kanamycin, 2,Ogm, im plus trimethoprim-sulfamethoxazole, 9 tahlets, PO; 112 of l23 patients were followed and 7(6.3%) failed. There is no sign.ificant difference between the two groups (p>0. 05) The failure rates in PPNG urethritis were 14.3% and 8.0% in group A and group B respectively. There is a signficant difference in failure rate between the two groups (P<0.05). It is suggested that, because of high rate of PPNG among circulating N.gonorrhoeae, the combinatioin regimen of kanamycin and trime.thoprim-sulfamethoxazole may be used as a first line treatrnent regimen for uncomplicated gonococcal urethritis.
