Prenatal Diagnosis of Recurrent Trisomy 18 Syndrome.
- Author:
Jin Yeong HAN
1
;
Kyeong Hee KIM
;
Myoung Seok HAN
;
Goo Hwa JE
;
Joong Pyo KIM
;
Lisa G SHAFFER
Author Information
1. Department of Laboratory Medicine, Dong-A University College of Medicine, Busan Korea. jyhan@daunet.donga.ac.kr
- Publication Type:Original Article
- Keywords:
Trisomy 18;
Recurrence;
Prenatal diagnosis;
Amniocentesis;
Maternal meiotic nondisjunction
- MeSH:
Amniocentesis;
Down Syndrome;
Fetus;
Humans;
Infant;
Karyotype;
Meiosis;
Parents;
Parturition;
Prenatal Diagnosis*;
Recurrence;
Trisomy*
- From:The Korean Journal of Laboratory Medicine
2003;23(1):67-69
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Though data on the recurrent risk after the birth of one fetus or infant with trisomy 18 is sparse, it has been presumed that the recurrence risk would be lower than the 1% for full trisomy 21 syndrome cases. We report a rare recurrent trisomy 18 found in amniocentesis in a family in which both parents had normal blood karyotype. Molecular analysis was undertaken in the second episode of trisomy 18 and a maternal meiosis II nondisjunction error was diagnosed.
