Factors Related to Refractory Macular Edema in Branch Retinal Vein Occlusion.
10.3341/jkos.2017.58.12.1367
- Author:
Ji Hyun PARK
1
;
Jung Min PARK
Author Information
1. Department of Ophthalmology, Maryknoll Medical Center, Busan, Korea. pjm1438@hanmail.net
- Publication Type:Original Article
- Keywords:
Bevacizumab;
Branch retinal vein occlusion;
Electroretinogram;
Hyperreflective foci;
Subfoveal choroidal thickness
- MeSH:
Bevacizumab;
Choroid;
Diabetes Mellitus;
Humans;
Hypertension;
Logistic Models;
Macular Edema*;
Retinal Vein Occlusion*;
Retinal Vein*;
Retinaldehyde*;
Retrospective Studies;
Risk Factors;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2017;58(12):1367-1375
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the factors associated with refractory macular edema (ME) secondary to branch retinal vein occlusion (BRVO) after three times of intravitreal bevacizumab (IVB) injections. METHODS: Ninety eyes of Ninety patients, who were retrospectively reviewed, were treated with IVB of 1.25 mg (0.05 mL) for ME secondary to BRVO, repeated three times at 4-week intervals and then followed-up for at least 4 months after the IVB. The patients were classified as refractory if there was an increase in the mean retinal thickness >150 µm when measured 1 month after the three injections. The patients were divided into two groups: a responsive group (46 eyes) and a refractory group (44 eyes). RESULTS: In univariate logistic regression analyses, age, diabetes mellitus, hypertension, visual acuity, maximal combined response b wave amplitude (Max B amp), maximal combined response B/A ratio (Max B/A), cone response b wave amplitude, subfoveal choroidal thickness (SFCT), and the number of hyperreflective foci (HF) were risk factors for refractory ME of BRVO (p = 0.045, p = 0.010, p = 0.037, p = 0.034, p = 0.003, p = 0.004, p = 0.001, p = 0.001 and p = 0.001, respectively). In backward multivariate logistic regression analyses, age, Max B amp, Max B/A, SFCT and number of HF were risk factors for refractory ME of BRVO (p = 0.024, p = 0.004, p = 0.047, p = 0.033 and p = 0.049, respectively). CONCLUSIONS: Baseline age, Max B amp, Max B/A, SFCT and number of HF predicted the probability of refractory ME secondary to BRVO after IVB.
