Inhibitory effects of biochanin A on mouse lung tumor induced by benzo(a)pyrene.
10.3346/jkms.1991.6.4.325
- Author:
Yun Sil LEE
1
;
Jeong Sun SEO
;
Hun Taeg CHUNG
;
Ja June JANG
Author Information
1. Laboratory of Cancer Pathology, Korea Cancer Center Hospital, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Biochanin A;
Mouse lung tumor;
Benzo(a)pyrene;
Carcinogenesis
- MeSH:
Animals;
Animals, Newborn;
Anticarcinogenic Agents/*pharmacology;
Benzo(a)pyrene;
Body Weight/drug effects;
Female;
*Genistein;
Incidence;
Isoflavones/*pharmacology;
Lung Neoplasms/chemically induced/*prevention & control;
Mice;
Neoplasms, Multiple Primary/chemically induced/prevention & control;
Survival Analysis
- From:Journal of Korean Medical Science
1991;6(4):325-328
- CountryRepublic of Korea
- Language:English
-
Abstract:
Biochanin A, an isoflavone compound, is reported to have an inhibitory effect on benzo(a)pyrene [B(a)P] metabolism. We examined the modifying effect of biochanin A on in vivo carcinogenesis using a mouse lung tumor model. As carcinogens, a single subcutaneous injection of 0.5mg of B(a)P was given within 24 hours after birth. The test groups were injected with 0.125mg of biochanin A in 0.1ml DMSO by i.p. 3 times a week for 6 weeks after weaning. All mice were sacrificed at week 9 and the incidence and multiplicity of lung tumors were examined. Concomitant administration of biochanin A showed a significant inhibitory effect on the incidence of tumor-bearing mice (12.5%, P<0.01), as well as the mean number of tumors (0.13, P<0.001), compared with the group treated with B(a)P alone in which the incidence was 57.1% and the mean number was 1.0. These results suggest that biochanin A has inhibitory potential on the development of mouse lung tumor induced by B(a)P.
