The experimental study of the bone regeneration on beta-TCP in rabbit cranial bone.
- Author:
Sung Hoon LEE
1
;
Seung Il SONG
;
Ji Young HAN
;
Kyung Gyun HWANG
;
Sung Sam PAIK
;
Kwang Sup SHIM
Author Information
1. Division of Oral and Maxillofacial Surgery, College Of Medicine, Hanyang UniversityHospital.
- Publication Type:Original Article
- Keywords:
Rabbit;
Cranial bone;
beta-TCP;
BMP 2/4;
Immunohistochemical analysis
- MeSH:
Animals;
Bone Regeneration*;
Humans;
Osteogenesis;
Parietal Bone;
Rabbits;
Regeneration;
Transplants
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2004;30(4):282-291
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pure-phase beta-tricalcium phosphate(beta-TCP) proved to be a bone regeneration material, providing the patient with vital bone at the defect site in a reasonable time, making a second surgical procedure for bone harvesting unnecessary. This study compares bone healing and BMP 2/4 expression in cranial defects in rabbits grafted with autogenous bone and beta-TCP. Thirty New Zealand White rabbits was divided into 3 group of 10 animals each. Bilateral calvarial defects were made in the parietal bones of each animal. beta-TCP placed in one defect and the other defects was filled with autogenous bone. The animal were sacrificed at 4, 8 and 12 weeks. Immunohistochemical analysis was used to investigate the expression of BMP 2/4. 1. The new bone formation around autogenous bone from 4 weeks and beta-TCP from 8 weeks. 2. In autogenous bone graft, BMP 2/4 expression was decreased from 4 to 12 weeks. 3. In beta-TCP graft, BMP 4 expression was increased from 8 to 12 weeks. But, BMP 2 was observed from 12 weeks. This study showed that bone healing, regeneration and, BMP 2/4 expression are delayed in grafted beta-TCP than autogenous bone.
