Prevalence and Clinical Characteristics of Recently Diagnosed Type 2 Diabetes Patients with Positive Anti-Glutamic Acid Decarboxylase Antibody.
10.4093/dmj.2012.36.2.136
- Author:
Yul HWANGBO
1
;
Jin Taek KIM
;
Eun Ky KIM
;
Ah Reum KHANG
;
Tae Jung OH
;
Hak Chul JANG
;
Kyong Soo PARK
;
Seong Yeon KIM
;
Hong Kyu LEE
;
Young Min CHO
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ymchomd@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetes mellitus, type 1;
Diabetes mellitus, type 2;
Glutamate decarboxylase
- MeSH:
Adult;
C-Peptide;
Diabetes Mellitus, Type 1;
Diabetes Mellitus, Type 2;
Fasting;
Glucose;
Glutamate Decarboxylase;
Humans;
Insulin;
Korea;
Plasma;
Prevalence;
Selection Bias
- From:Diabetes & Metabolism Journal
2012;36(2):136-143
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Latent autoimmune diabetes in adults (LADA) refers to a specific type of diabetes characterized by adult onset, presence of islet auto-antibodies, insulin independence at the time of diagnosis, and rapid decline in beta-cell function. The prevalence of LADA among patients with type 2 diabetes varies from 2% to 20% according to the study population. Since most studies on the prevalence of LADA performed in Korea were conducted in patients who had been tested for anti-glutamic acid decarboxylase antibody (GADAb), a selection bias could not be excluded. In this study, we examined the prevalence and clinical characteristics of LADA among adult patients recently diagnosed with type 2 diabetes. METHODS: We included 462 patients who were diagnosed with type 2 diabetes within 5 years from the time this study was performed. We measured GADAb, fasting insulin level, fasting C-peptide level, fasting plasma glucose level, HbA1c, and serum lipid profiles and collected data on clinical characteristics. RESULTS: The prevalence of LADA was 4.3% (20/462) among adult patients with newly diagnosed type 2 diabetes. Compared with the GADAb-negative patients, the GADAb-positive patients had lower fasting C-peptide levels (1.2+/-0.8 ng/mL vs. 2.0+/-1.2 ng/mL, P=0.004). Other metabolic features were not significantly different between the two groups. CONCLUSION: The prevalence of LADA is 4.3% among Korean adult patients with recently diagnosed type 2 diabetes. The Korean LADA patients exhibited decreased insulin secretory capacity as reflected by lower C-peptide levels.
