Performance evaluation of AmicusTM and MCS + during plateletpheresis.
- Author:
So Yong KWON
1
;
Deok Ja OH
;
Ok Im CHOI
;
Hee Sook HAN
;
Nam Sun CHO
;
Sang In KIM
Author Information
1. Blood Transfusion Research Institute, Central Red Cross Blood Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
AmicusTM;
MCS +;
plateletpheresis
- MeSH:
Blood Platelets;
Citric Acid;
Humans;
Incidence;
Platelet Count;
Plateletpheresis*;
Tissue Donors
- From:Korean Journal of Blood Transfusion
2001;12(1):27-34
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Recently introduced plateletpheresis systems (AmicusTM software version 2.41 and MCS + LDP Rev. C) were evaluated for their performance. METHOD: Single-needle procedure was used for all donors, 127 with the AmicusTM and 85 with the MCS +. The targeted platelet yield was 3.2x1011. Components were evaluated for component yields, collection time, collection efficiency and incidence of donor reactions due to citrate. RESULTS: The collection time was significantly shorter with the AmicusTM (mean 57 min vs. 71 min, p< 0.05), and in 9 donors with a mean preapheresis platelet count of 325x103 /microliter the whole procedure could be completed within 40 minutes. However, the total processing time, including preprocessing and postprocessing time, between AmicusTM (78.0 min) and MCS + (74.3 min) was not statistically different. Mean platelet yield for AmicusTM and MCS + were 3.6x1011 and 3.4x1011, respectively. With 82.4% of SDPs collected with the MCS + having a platelet count of 3.0~3.9x1011, compared to 65.4% with the AmicusTM, the MCS + was more accurate in predicting the platelet yield of the final products. All components showed a residual WBC count of 5.0x106, and in 99.2% and 97.6% of components collected with the AmicusTM and MCS +, respectively, had a residual WBC count of less than 1.0x106. Mild donor reactions due to citrate tended to be more common on the MCS + (14.1%), which also used significantly more ACD (mean 342.5 mL vs. 268.0 mL, p< 0.05), than on the AmicusTM (5.5%). CONCLUSION: The plateletpheresis systems evaluated in this study allow the collection of leukoreduced SDPs of high quality within a reasonable time.
