Subcortical Deformities in Schizophrenic Patients and Unaffected Siblings.
10.4306/jknpa.2012.51.5.241
- Author:
Seung Ha HWANG
1
;
Ji Woong KIM
;
Jeewook CHOI
;
Sun Woo LEE
;
Bumseok JEONG
Author Information
1. Department of Psychiatry, Eulji University College of Medicine, Eulji University Hospital, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Unaffected sibling;
Shape analysis;
Subcortex;
Magnetic resonance imaging
- MeSH:
Congenital Abnormalities;
Genetic Predisposition to Disease;
Humans;
Magnetic Resonance Imaging;
Magnetic Resonance Spectroscopy;
Multivariate Analysis;
Neuroimaging;
Nucleus Accumbens;
Putamen;
Reward;
Schizophrenia;
Siblings;
Thalamus
- From:Journal of Korean Neuropsychiatric Association
2012;51(5):241-248
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Abnormalities in various subcortical regions have been reported in previous structural neuroimaging studies for schizophrenia. To understand the subcortical abnormalities as a whole, all subcortical regions should be explored in each subject unlike most previous studies. Here, we explored major subcortical structures using volume measurement and shape analysis for schizophrenic patients (SZ), their unaffected siblings (Sib) and healthy controls without affected sibling (HC). METHODS: Structural magnetic resonance images were acquired from 24 SZ, 24 Sib and 19 HC. Both segmentation and shape analysis for subcortical structures was performed using FMRIB Integrated Registration and Segmentation Tool integrated within the FSL software. The group comparison of subcortical volumes was performed with multivariate analysis of variance (MANOVA). RESULTS: In SZ group, shape deformities were observed in the left nucleus caudates, left thalamus, left putamen and bilateral pallidus were increased compared with HC group. In Sib group, shape deformities were observed in the left pallidus, left putamen and left putamen was decreased compared with HC group. In Sib group, left nucleus accumbens was increased compared with SZ group. CONCLUSION: The result of this study using volume measurement and shape analysis suggest that subcortical structural abnormalities in cortico-striato-pallido-thalamic and reward circuits are related with both the pathology of schizophrenia and genetic predisposition.
