Artificial Liver Devices and Bioartificial Liver Systems: Current Status.
10.4285/jkstn.2011.25.1.15
- Author:
Choon Hyuck David KWON
1
;
Suk Koo LEE
;
Jung Keug PARK
;
Doo Hoon LEE
;
Ji Hyun LEE
Author Information
1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. sklee3464@skku.edu
- Publication Type:Review ; Clinical Trial
- Keywords:
Bioartificial liver;
Artificial liver;
Acute liver failure;
Calcium alginate;
Hepatic transplantation
- MeSH:
Alginates;
Bioreactors;
Biotransformation;
Glucuronic Acid;
Hepatocytes;
Hexuronic Acids;
Humans;
Korea;
Liver;
Liver Failure;
Liver Failure, Acute;
Liver Transplantation;
Liver, Artificial;
Transplants
- From:The Journal of the Korean Society for Transplantation
2011;25(1):15-21
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute liver failure is a rapidly progressive disease of the liver associated with high morbidity and mortality without liver transplantation. Although good survival after transplantation can be achieved, due to the disparity between patients awaiting transplantation and available organs, many patients die due to progression of the disease while waiting for a liver graft. To reduce the high morbidity and mortality associated with acute liver failure, attempts have been made during the last several decades to develop a temporary liver support system, such as artificial and bioartificial livers. The artificial liver is a non-biological device mainly aimed at the removal of accumulated toxins during liver failure, and the bioartificial liver is a biological device that has bioreactors containing living hepatocytes which provide both biotransformation and synthetic liver functions. There are currently 3 artificial livers available in the market that have been actively used in the clinical field, and 11 bioartificial livers that have been developed and have undergone clinical trials. In this article, we will discuss about the 3 artificial liver devices and 5 bioartificial liver systems that are the most advanced and have been widely evaluated clinically. Also, the characteristics and the preclinical data of the first bioartificial liver system developed in Korea that is currently under clinical investigation, will be discussed.
