Serial Follow-up of Neuroimaging Findings in a Progression-free Survival Case with Progressive Multifocal Leukoencephalopathy in Nonimmunocompromised Child.
- Author:
Won Young DOH
1
;
Yang Je CHO
;
Soo Chul PARK
;
Jong Doo LEE
;
Dong Soo KIM
;
Tai Seung KIM
;
Il Nam SUNWOO
;
Joong Un CHOI
Author Information
1. Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. scpark@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Progressive multifocal leukoencephalopathy;
Nonimmunocompromised;
Longterm-survival
- MeSH:
Brain;
Child*;
Demyelinating Diseases;
Diagnosis;
Disease-Free Survival*;
Follow-Up Studies*;
Humans;
Leukoencephalopathy, Progressive Multifocal*;
Magnetic Resonance Imaging;
Neuroimaging*;
Oligodendroglia;
Opportunistic Infections;
Tomography, Emission-Computed, Single-Photon
- From:Journal of the Korean Neurological Association
2004;22(5):524-528
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Progressive multifocal leukoencephalopathy (PML) is a demyelination disease caused by opportunistic infection of the ubiquitous, usually nonpathogenic neurotropic papovavirus (JC virus). The virus infects and destroys myelin-producing oligodendrocytes, thereby causing patchy areas of demyelination in the cerebral white matter. It is exclusively a disease of immunosuppressed individuals. We report a case of an immunocompetent child patient with pathologically-proven PML and with a survival over 3 years after diagnosis. Serial follow up of neuroimaging study including brain MRI, MRS, SPECT and PET was obtained.
