Effects of supplementation of folic acid, multiminerals, DHA on fertility rate of rats and growth and learning ability of their offsprings.
- Author:
Seong Jo KIM
1
;
Tae Yel HA
;
Chan Kyu HAN
;
Na Young KIM
;
Hong Seok AHN
;
Hyeon Kyeong SHIN
;
Seong Ju SHIN
;
Sung Woon CHANG
;
Jung Noh LEE
;
Joon Kyu LIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA university School of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Fertility rate;
Folic acid;
Zinc;
DHA;
Learning ability
- MeSH:
Animals;
Birth Rate*;
Birth Weight;
Calcium;
Child;
Corpus Luteum;
Diet;
Estradiol;
Female;
Femur;
Fertility*;
Folic Acid*;
Humans;
Iron;
Learning*;
Male;
Malnutrition;
Nutrition Disorders;
Ovary;
Parturition;
Pregnancy;
Pregnancy Outcome;
Progesterone;
Rats*;
Taurine;
United Nations;
Zinc
- From:Korean Journal of Obstetrics and Gynecology
2002;45(9):1588-1594
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Malnutrition and nutritional disorder may cause problem of fertility and therefore adequate nutrition is very important during pregnancy. In this study, we investigated effects of supplemental diet contained folic acid, zinc, calcium, Iron, DHA and taurine on fertility outcome in the female rats and learning ability of their offsprings. METHODS: The female rats at 4 week were fed by two group divided control (AIN-76 diet) and supplement diet. The male rats were taken pellet type diet. After 3 weeks, female rats and male rats were mated. Then, at 3 weeks after mating, parturition was begun. After paturition, sex and birth weight of offsprings were examined for their offsprings. When the offsprings were 3 weeks of age, position reversional test in a water maze was done for 4 weeks. After female rats were fed experimental diet for 4 weeks, their follicle, corpus luteum, corpus albicans, progesterone, estradiol and ovary weight were measured. RESULTS: 22 rats of 30 in supplemental diet group succeeded on parturition, and 11 rats of 30 in control group succeeded. Pregnancy outcome was fine in both group. There was no significant difference in weight of major bowels and femur length of their offspring. The position reversional test of offsprings in a water maze showed a significant difference between control group and supplement group. Elapsed time and errorneous response to reach the escape platform were significantly lowered in supplemental group than control group. CONCLUSION: This result suggest that supplementation contained folic acid, multivitamins, DHA and taurine may increase fertility rate in the maternal rats and also learning ability in offsprings.
