A Case of Intramedullary Myelopathy Associated with Small Cell Lung Cancer.
- Author:
Heui Soo MOON
1
;
B Joon KIM
;
Sang Moo LEE
Author Information
1. Department of Neurology, School of Medicine, Sungkyunkwan University.
- Publication Type:Case Report
- Keywords:
Paraneoplastic syndrome;
Myelopathy;
Antineuronal nuclear antibody-1;
Small cell lung cancer
- MeSH:
Anesthesia;
Drug Therapy;
Humans;
Lower Extremity;
Male;
Middle Aged;
Paraneoplastic Syndromes;
Paraparesis;
Radiotherapy;
Small Cell Lung Carcinoma*;
Spinal Cord Diseases*;
Spine;
Urinary Bladder
- From:Journal of the Korean Neurological Association
2000;18(1):98-101
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Subacute paraneoplastic myelopathy is a rare cause of myelopathy. Serepositivity for antineuronal nuclear antibodies-1(ANNA-1, Anti-Hu) is a sensitive and specific marker for the paraneoplastic syndrome with small cell lung cancer. A 57-year-old male patient was admitted because of acutely progressive paraparesis, anesthesia of both lower limbs and loss of bladder function over 3 days. He was subsequently found to have small cell lung carcinoma of limited stage. Magnetic resonance image of the thoracic spine showed signal abnormalities with mild focal enhancement in the intramedullary portion of C7-T10 segments. Concurrent CSF cytology showed no abnormal findings. He had high sero-logic titer of ANNA-1. These findings suggest of a paraneoplastic syndrome although we didn't have nectrotic patholog-ic findings. Five months after onset of neurological symptoms, he died inspite of chemotherapy and radiotherapy. We report a case of intramedullary myelopathy, probably of paraneoplastic origin, associated with small cell lung cancer.
