A Case of Rhabdomyolysis after Doxylamine Overdose.
- Author:
Jong Chul KIM
1
;
Sang Ahm LEE
Author Information
1. Department of Neurology, Asan Medical Center, College of Medicine, Ulsan University.
- Publication Type:Case Report
- Keywords:
Rhabdomyolysis;
Doxylamine;
Antihistamine;
Renal failure
- MeSH:
Acute Kidney Injury;
Adjustment Disorders;
Creatine Kinase;
Dilatation;
Doxylamine*;
Female;
Humans;
Pupil;
Renal Dialysis;
Renal Insufficiency;
Rhabdomyolysis*;
Seizures;
Succinic Acid;
Tachycardia;
Vomiting;
Young Adult
- From:Journal of the Korean Neurological Association
2000;18(1):119-120
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of non-traumatic rhabdomyolysis after overdose of doxylamine succinate. A 22-year-old woman with reactive depression had an overdose of doxylamine with suicidal intent. She had decreased mental state, confusion, convulsion, vomiting, tachycardia, pupil dilatation, and ocular flutter. Serum creatine phosphokinase concentra-tion was 6,752 IU/L initially, increased to maximum (165,590 IU/L) at the third day, and then rapidly decreased and returned to normal 2 weeks after intoxication. Acute renal failure occurred but was resolved without hemodialysis. Rhabdomyolysis associated with renal failure is a rare but serious complication after doxylamine overdose.
