A Case of Acquired Hemophilia A.
- Author:
Jeong Hun KIM
1
;
Woo In LEE
;
Hwi Joong YOON
;
Sui Yon PARK
;
Jin Tae SUH
;
Hee Joo LEE
Author Information
1. Department of Laboratory Medicine, College of Medicine Kyung Hee University, Seoul, Korea. wileemd@khu.ac.kr
- Publication Type:Case Report
- Keywords:
Acquired hemophilia;
Activated partial thromboplastin time;
Factor VIII inhibitor
- MeSH:
Aged;
Arthritis, Rheumatoid;
Autoantibodies;
Factor VIII;
Gastrectomy;
Hematuria;
Hemophilia A*;
Hemorrhage;
Humans;
Kidney Pelvis;
Partial Thromboplastin Time;
Recurrence;
Stomach Neoplasms;
Thromboplastin
- From:Journal of Laboratory Medicine and Quality Assurance
2003;25(1):207-209
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acquired hemophilia is a rare acquired bleeding disorder. It occurs most frequently in elderly patients and in patients with associated underlying diseases such as autoimmune disorders, rheumatoid arthritis, malignancies, and so on. It is caused by autoantibodies to factor VIII which deplete circulating factor VIII. We report a 78-year-old man with acquired hemophilia A who underwent subtotal gastrectomy for stomach cancer 7 years ago with no current evidence of recurrence. He has no bleeding tendency in the past nor family history for bleeding. On admission he had blood clots in both renal pelvis and sustaining hematuria. Laboratory tests revealed prolonged activated partial thromboplastin time(aPTT), decreased activity of factor VIII and evidence of factor VIII inhibitor.
