Clinicopathologic Characteristics of Hepatocellular Carcinoma with Extrahepatic Malignancy.
- Author:
Dongho CHOI
1
;
Hanjoon KIM
;
Kyeong Geun LEE
;
Hwon Kyum PARK
;
Oh Jung KWON
;
Kwang Soo LEE
Author Information
1. Department of Surgery, College of Medicine, Hanyang University, Seoul, Korea. leeks@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatocellular carcinoma;
Extrahepatic malignancy
- MeSH:
Carcinoma, Hepatocellular*;
Female;
Follow-Up Studies;
Gastrectomy;
Humans;
Male;
Mastectomy, Segmental;
Rare Diseases;
Rectal Neoplasms;
Retrospective Studies;
Stomach Neoplasms
- From:Journal of the Korean Surgical Society
2003;64(6):487-492
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Multiple primary cancers are not a rare disease. The clinicopathologic characteristics of a hepatocellular carcinoma with extrahepatic malignancies, have not been identified. To address these points, the clinical data of patients with a hepatocellular carcinoma, with extrahepatic malignancies, treated with surgical resections at our hospital, were retrospectively reviewed. METHODS: We reviewed the clinical records of ten hepatocellular carcinoma patients, with extrahepatic malignancies, who had undergone an operation between January, 1986 and December, 2002 at the Hanyang University Hospital. RESULTS: 10 patients were comprised of 9 males and 1 female, with a mean age of 58.6 years, ranging from 34 to 75. There were 9 stomach cancers and 1 rectal cancer extrahepatic malignancies associated with the hepatocellular carcinomas. Four of these were synchronous type and six were metachronous type. The treatments used for the HCCs were: 1 extended right lobectomy, 6 right lobectomies, 1 each of a TAE with RFTA, a segmentectomy with RFTA, and a segmentectomy. The operations for the extrahepatic malignancies included 1 low anterior resection, for the rectal cancer and 9 subtotal gastrectomies, for the stomach cancers. During the mean follow up time of 66.1 months, five patients survived and five died. CONCLUSION: Patients who have a hepatocellular carcinoma, associated with extrahepatic malignancies, have been treated with aggressive operations and combination therapies. Stomach cancer is the most common extrahepatic malignancy associated with a hepatocellular carcinoma.
