New Perspectives on Diabetic Vascular Complications: The Loss of Endogenous Protective Factors Induced by Hyperglycemia.
- Author:
In Kyung JEONG
1
;
George L KING
Author Information
- Publication Type:Review
- Keywords: Diabetic vascular complication; Hyperglycemia; Platelet derived growth factor; Vascular endothelial growth factor
- MeSH: Diabetic Angiopathies; Dyslipidemias; Humans; Hyperglycemia; Insulin; Oxidative Stress; Platelet-Derived Growth Factor; Protein Kinase C; Sorbitol; Vascular Endothelial Growth Factor A
- From:Diabetes & Metabolism Journal 2011;35(1):8-11
- CountryRepublic of Korea
- Language:English
- Abstract: Diabetic vascular complications are among the leading causes of morbidity and mortality in diabetic patients. In the past, many studies have focused on the mechanisms of hyperglycemia-induced chronic vascular complications via the formation of toxic metabolites such as oxidative stress, advanced glycosylated end products, persistent activation of protein kinase C, and increased sorbitol concentrations. However, vascular complications result from imbalances caused by increases in systemic toxic metabolites, such as those that occur under conditions of hyperglycemia and dyslipidemia, and by reductions in endogenous protective factors such as insulin, vascular endothelial growth factor, and platelet derived growth factor. This review outlines some of the evidence supporting the importance of enhancing endogenous regenerative factors.
