A Case of Reversible Posterior Leukoencephalopathy Syndrome in Patient with Chronic Renal Failure.
- Author:
Young Sun KOO
1
;
Do Hee KIM
;
Yoon Kyung CHANG
;
Jong Oh YANG
;
Min Gyu KANG
;
Pyeong Joo HWANG
;
Chang June SONG
;
Kang Wook LEE
;
Young Tai SHIN
Author Information
1. Department of Internal Medicine, Chungnam National University Hospital, Taejon, Korea. kwlee@hanbat.chungnam.ac.kr
- Publication Type:Case Report
- Keywords:
Posterior leukoencephalopathy syndrome;
Blindness;
Chronic renal failure
- MeSH:
Blindness;
Blood Pressure;
Brain;
Consciousness;
Cyclosporine;
Eclampsia;
Edema;
Female;
Follow-Up Studies;
Headache;
Humans;
Hypertensive Encephalopathy;
Immunosuppressive Agents;
Kidney Failure, Chronic*;
Leukoencephalopathies;
Magnetic Resonance Imaging;
Neuroimaging;
Neurologic Manifestations;
Occipital Lobe;
Posterior Leukoencephalopathy Syndrome*;
Pre-Eclampsia;
Pregnancy;
Rabeprazole;
Renal Insufficiency;
Seizures;
Tacrolimus;
Vomiting;
Young Adult
- From:Korean Journal of Nephrology
2001;20(1):127-131
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A Reversible Posterior Leukoencephalopathy Syndrome(RPLS) consists of neurologic symptoms and signs - headache, consciousness change, seizure, visual impairment - and brain imaging finding showing brain(espicially white matter) edema usually involving the posteior parietal-temporal-occipital areas. The causes are thought to be hypertensive encephalopathy, pre-eclampsia or eclampsia, renal failure with fluid overload and immunosuppressive agents such as cyclosporin A or FK506. RPLS may usually reversible if treated early by decreasing blood pressure and discontinuing offending drugs. A 23-year-old man had been hemodialyzed with chronic renal failure for two years. His blood pressure elevated to 240/150mmHg 3 days before admission and he complained of severe headache, vomiting, and total visual loss at the day of admission. Brain T2-weighted MRI imaging showed increased signal intensity involving the both parietal, posterior temporal, and occipital lobes. After antihypertensive and dexamethason treatment, a follow-up brain MRI performed on 7 days after admission showed nearly normalized findings and all symptoms including visual loss were recovered completely in one week.
