A Case of Reversible Posterior Leukoencepalopathy Syndrome during Steroid Therapy in a Down Syndrome with Nephrotic Syndrome.
- Author:
Ji Eun LEE
1
;
Byung Soo KIM
;
Ho Il LEE
;
Min Suk CHOI
;
Sung Woo CHUNG
;
Seung Hun LEE
;
Euy Jin CHOI
;
Byung Kee BANG
Author Information
1. Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Korea. kbsnep@chollian.net
- Publication Type:Case Report
- Keywords:
Reversible posterior, leukoencepalopathy syndrome;
Nephrotic syndrome;
Steroid
- MeSH:
Adolescent;
Blindness;
Down Syndrome*;
Female;
Follow-Up Studies;
Head;
Headache;
Humans;
Hypertension;
Immunosuppressive Agents;
Inflammation;
Nephrotic Syndrome*;
Occipital Lobe;
Posterior Leukoencephalopathy Syndrome;
Prednisolone;
Rabeprazole;
Seizures;
Temporal Lobe;
Tomography, X-Ray Computed
- From:Korean Journal of Nephrology
2001;20(1):143-146
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The reversible posterior leukoencephalopathy syndrome usually includes seizure, headache, altered mental status, and blindness, often associated with hypertension and immunosuppressants. The authors discuss a 16-year-old female with Down syndrome who had nephrotic syndrome with severe headache, intermittent blindness, and seizures, after treated with prednisolone. The patient had a generalized tonic-clonic seizure at 8 days after prednisolone. A CT scan of the head revealed symmetrical multifocal low densities in the subcortical region of both parieto-occipital, frontal, temporal lobe. Magnetic resonance scanning revealed white matter lesions in the subcortices of the parietal, frontal and occipital lobes. The condition improved when prednisolone was discontinued. Follow-up image after 3 weeks shows nearly complete resolution of white matter and gray matter abnormalities on axial T2-weighted MR images. This episode might be caused by prednisolone because the clinical course and laboratory data revealed neither inflammation nor other causative factors.
