Experimental Evaluation of Intravitreal Perfluorodecalin and Silicone Oil in the Rabbit as a Long-acting Intraocular Tamponade.
- Author:
Hyung Woo KWAK
1
;
Dae Ho KIM
;
Jae Myung KIM
Author Information
1. Department of Ophthalmology, College of Medicine, Kyung Hee University, Korea.
- Publication Type:Original Article
- Keywords:
Perfluorodecalin;
Silicone oil;
Vitrectomy;
Retinal toxicity
- MeSH:
Rabbits;
Retina;
Silicone Oils*;
Vitrectomy;
Vitreoretinopathy, Proliferative
- From:Journal of the Korean Ophthalmological Society
1995;36(4):626-635
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Perfluorodecalin, which is one of the perfluorocarbon liquids, is not established safety in use of long-acting intraocular tamponade. Therefore, to determine its safety we injected it alone and combined with silicone oil into the vitreous of vitrectomized eyes. We evaluated the changes of the fundus, electroretinogram, histopathology as light and electron microgragh after lensectomy and vitrectomy in pigmented rabbits periodically. In rabbits replaced with perfluorodecalin alone, fundus showed mild proliferative vitreoretinopathy and micrographs showed the destruction of the inner and outer segments of the photoreceptors. In rabbits replaced with perfluorodecalin and silicone oil, fundus showed more severe proliferative vitreoretinopathy than perfluorodecalin alone and micrographs showed the destruction of the entire retina. In electroretinogram, the amplitude was decreased markedly. So, it is considered that perfluorodecalin was not tolerant in case of longacting intraocular tamponade and also perfluorodecalin combined with silicone oil developed severe proliferative vitreoretinopathy.
