Assessment of glomerular filtration rate with dynamic computed tomography in normal Beagle dogs.
10.4142/jvs.2011.12.4.393
- Author:
Jinhwa CHANG
1
;
Sujin KIM
;
Joohyun JUNG
;
Heechun LEE
;
Hojung CHOI
;
Dongwoo CHANG
;
Youngwon LEE
;
Junghee YOON
;
Mincheol CHOI
Author Information
1. Department of Medical Imaging, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Korea. mcchoi@snu.ac.kr
- Publication Type:Original Article
- Keywords:
computed tomography;
dog;
glomerular filtration rate
- MeSH:
Animals;
Dogs/*physiology;
Female;
Glomerular Filtration Rate/*physiology;
Male;
Reference Values;
Tomography, X-Ray Computed/methods/*veterinary
- From:Journal of Veterinary Science
2011;12(4):393-399
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of our study was to determine individual and global glomerular filtration rates (GFRs) using dynamic renal computed tomography (CT) in Beagle dogs. Twenty-four healthy Beagle dogs were included in the experiment. Anesthesia was induced in all dogs by using propofol and isoflurane prior to CT examination. A single slice of the kidney was sequentially scanned after a bolus intravenous injection of contrast material (iohexol, 1 mL/kg, 300 mgI/mL). Time attenuation curves were created and contrast clearance per unit volume was calculated using a Patlak plot analysis. The CT-GFR was then determined based on the conversion of contrast clearance per unit volume to contrast clearance per body weight. At the renal hilum, CT-GFR values per unit renal volume (mL/min/mL) of the right and left kidneys were 0.69 +/- 0.04 and 0.57 +/- 0.05, respectively. No significant differences were found between the weight-adjusted CT-GFRs in either kidney at the same renal hilum (p = 0.747). The average global GFR was 4.21 +/- 0.25 mL/min/kg and the whole kidney GFR was 33.43 +/- 9.20 mL/min. CT-GFR techniques could be a practical way to separately measure GFR in each kidney for clinical and research purposes.
