A Case of Steroid and Methotrexate-Resistant Eosinophilic Fasciitis Treated with Adalimumab.
10.4078/jrd.2011.18.4.306
- Author:
Sang Su LEE
1
;
Hyun Ok KIM
;
Jae Boem NA
;
Jong Sil LEE
;
Young Sun SUH
;
Yun Hong CHEON
;
Min Gyu KANG
;
Yu eun KIM
;
Sang Il LEE
Author Information
1. Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. goldgu@gnu.ac.kr
- Publication Type:Case Report
- Keywords:
Eosinophilic fasciitis;
Glucocorticoid;
TNF alpha inhibitor
- MeSH:
Antibodies, Monoclonal, Humanized;
Eosinophilia;
Eosinophils;
Extremities;
Fascia;
Fasciitis;
Glucocorticoids;
Immunosuppressive Agents;
Inflammation;
Korea;
Sclerosis;
Adalimumab
- From:Journal of Rheumatic Diseases
2011;18(4):306-310
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Eosinophilic fasciitis (EF) is a rare fibrosing disorder characterized by painful swelling and induration of the limbs and trunk, characteristic histology with sclerosis and lymphocytic inflammation affecting the fascia. The cause and pathogenesis of EF are still unknown and current therapies include glucocorticoids with or without use of immunosuppressive agents. Recently, there have been several case reports documenting the efficacy of a TNF alpha inEosinophilic fasciitis (EF) is a rare fibrosing disorder characterized by painful swelling and induration of the limbs and trunk, characteristic histology with sclerosis and lymphocytic inflammation affecting the fascia. The cause and pathogenesis of EF are still unknown and current therapies include glucocorticoids with or without use of immunosuppressive agents. Recently, there have been several case reports documenting the efficacy of a TNF alpha inhibitor in EF following a steroid-resistant disease course. However, there has been no report on the experience in treatment of EF with a TNF alpha inhibitor in Korea. Hence, we report a case of steroid and methotrexate-resistant EF which was successfully treated with adalimumab, along with a review of the relevant articles.
