Associations between Single Nucleotide Polymorphisms of High Mobility Group Box 1 Protein and Clinical Outcomes in Korean Sepsis Patients.
10.3349/ymj.2016.57.1.111
- Author:
Kwangha LEE
1
;
Youjin CHANG
;
Kyuyoung SONG
;
Yun Young PARK
;
Jin Won HUH
;
Sang Bum HONG
;
Chae Man LIM
;
Younsuck KOH
Author Information
1. Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
- Publication Type:Original Article
- Keywords:
High mobility group box 1;
single nucleotide polymorphisms;
rs1045411;
sepsis;
the variant A allele
- MeSH:
Adult;
Aged;
Alleles;
Asian Continental Ancestry Group/genetics;
China/epidemiology;
Cytokines/*blood/*genetics;
Female;
Genotype;
HMGB1 Protein/blood/*genetics;
Humans;
Interleukin-10/genetics;
Interleukin-17/genetics;
Interleukin-6/blood;
Male;
Middle Aged;
Polymorphism, Genetic/*genetics;
Polymorphism, Single Nucleotide/*genetics;
Prognosis;
Republic of Korea;
Sepsis/immunology/*metabolism/mortality;
Shock, Septic/immunology/*metabolism/mortality;
Survival;
Tumor Necrosis Factor-alpha/genetics
- From:Yonsei Medical Journal
2016;57(1):111-117
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: High mobility group box 1 (HMGB1) plays a central role in the pathogenesis of sepsis and multiple organ dysfunction syndromes. We investigated the associations of a single nucleotide polymorphism (SNP; rs1045411) in HMGB1 with various clinical parameters, severity, and prognosis in patients with sepsis, severe sepsis, or septic shock. MATERIALS AND METHODS: We enrolled 212 adult patients followed for 28 days. All patients were genotyped for rs1045411, and the serum levels of HMGB1 and several cytokines were measured. RESULTS: The proportions of patients according to genotype were GG (71.2%), GA (26.4%), and AA (2.4%). Among patients with chronic lung disease comorbidity, patients with a variant A allele had higher positive blood culture rates and higher levels of various cytokines [interleukin (IL)-1beta, IL-6, IL-10, IL-17, and tumor necrosis factor-alpha] than those with the GG genotype. In the analysis of those with diabetes as a comorbidity, patients with a variant A allele had higher blood culture and Gram-negative culture rates than those with GG genotypes; these patients also had a higher levels of IL-17. In the analysis of those with sepsis caused by a respiratory tract infection, patients with a variant A allele had higher levels of IL-10 and IL-17 (all p<0.05). This polymorphism had no significant impact on patient survival. CONCLUSION: The variant A allele of rs1045411 appears to be associated with a more severe inflammatory response than the GG genotype under specific conditions.
