Association between Toll-Like Receptor 9-1237T/C Polymorphism and the Susceptibility of Inflammatory Bowel Diseases: A Meta-Analysis.
10.3349/ymj.2016.57.1.153
- Author:
Jian SHANG
1
;
Xiaobing WANG
;
Wei WANG
;
Huaqin PAN
;
Shi LIU
;
Lixia LI
;
Liping CHEN
;
Bing XIA
Author Information
1. Department of Gastroenterology/Hepatology, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China. bingxia@aliyun.com
- Publication Type:Original Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
- Keywords:
Toll-like receptor 9;
-1237T/C;
polymorphism;
inflammatory bowel disease;
meta-analysis
- MeSH:
Alleles;
European Continental Ancestry Group/genetics;
Genetic Predisposition to Disease/*genetics;
Homozygote;
Humans;
Inflammatory Bowel Diseases/ethnology/*genetics;
Odds Ratio;
Polymorphism, Genetic/*genetics;
Risk Factors;
Toll-Like Receptor 9/*genetics/metabolism
- From:Yonsei Medical Journal
2016;57(1):153-164
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The -1237T/C polymorphism of the Toll-like receptor 9 (TLR9) gene has been implicated in the susceptibility of inflammatory bowel diseases (IBDs), but the results remain conflicting. We further investigated this association via meta-analysis. MATERIALS AND METHODS: Multiple electronic databases were extensively searched until February, 2015. The strength of association was evaluated by calculating the pooled odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: A total of 2987 cases and 2388 controls from eight studies were analyzed. Overall, association was found between TLR9 -1237T/C polymorphism and the risk of IBDs when all the studies were pooled (recessive model, OR: 1.59, 95% CI: 1.02-2.47, p=0.04; homozygote comparison, OR: 1.62, 95% CI: 1.04-2.52, p=0.03; allele model, OR: 1.13, 95% CI: 1.00-1.27, p=0.05). Stratification by ethnicity indicated an association between TLR9 -1237T/C polymorphism and IBDs risk in Caucasians (recessive model, OR: 1.59, 95% CI: 1.02-2.47, p=0.04; homozygote comparison, OR: 1.62, 95% CI: 1.04-2.52, p=0.03; allele model, OR: 1.12, 95% CI: 1.00-1.27, p=0.05). When stratified by disease type, significant correlation were only found in the Crohn's disease subgroup (recessive model, OR: 1.69, 95% CI: 1.05-2.73, p=0.03; homozygote model, OR: 1.74, 95% CI: 1.07-2.82, p=0.02; allele model, OR: 1.15, 95% CI: 1.01-1.32, p=0.04). CONCLUSION: The present study suggested that the TLR9 -1237T/C polymorphism might act as a risk factor in the development of IBDs, particularly in Caucasians.
