Valacyclovir-Induced Neurotoxicity in a Maintenance Hemodialysis Patient.
10.4235/jkgs.2014.18.2.85
- Author:
June Seong HWANG
1
;
Hyo Yoep SONG
;
Hoon Gil JO
;
Song I LEE
;
Byung Hun LIM
;
Jung Sub SONG
;
Seon Ho AHN
Author Information
1. Department of Internal Medicine, Wonkwang University College of Medicine, Iksan, Korea. ashneph@wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
End-stage renal disease;
Hemodialysis;
Neurotoxicity;
Valacyclovir
- MeSH:
Herpes Zoster;
Herpesviridae Infections;
Humans;
Kidney Failure, Chronic;
Renal Dialysis*
- From:Journal of the Korean Geriatrics Society
2014;18(2):85-88
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Valacyclovir is an oral antiviral agent used in the treatment of herpesvirus infection. Although neuropsychiatric symptoms may accompany the use of this drug, valacyclovir is increasingly used to treat herpes zoster, as it is more effective when orally administered. This paper reports one case of neurotoxicity of valacyclovir in patients with end stage renal disease who were undergoing maintenance hemodialysis. Valacyclovir can induce life-threatening neurotoxicity, especially in end stage renal disease patients despite the appropriate dose reduction. Furthermore, Valacyclovir-induced neurotoxicity can be effectively managed by intensive hemodialysis.
