Clinical Significance of Wnt/beta-Catenin Signalling and Androgen Receptor Expression in Prostate Cancer.
10.5534/wjmh.2013.31.1.36
- Author:
Soo Jin JUNG
1
;
Sangtaek OH
;
Geun Taek LEE
;
Jaeil CHUNG
;
Kweonsik MIN
;
Jangho YOON
;
Wansuk KIM
;
Dong Soo RYU
;
Isaac Yi KIM
;
Dong Il KANG
Author Information
1. Department of Pathology, Inje University College of Medicine, Busan, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
Prostate neoplasms;
Beta catenin;
Matrix metalloproteinases;
Receptors, androgen;
Prognosis
- MeSH:
Antibodies;
beta Catenin;
Biopsy, Needle;
Cell Line;
Cytoplasm;
Disease Progression;
Humans;
Matrix Metalloproteinase 7;
Matrix Metalloproteinases;
Neoplasm Metastasis;
Prognosis;
Prostate;
Prostate-Specific Antigen;
Prostatectomy;
Prostatic Neoplasms;
Receptors, Androgen
- From:The World Journal of Men's Health
2013;31(1):36-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the relationships among the Wnt/beta-catenin pathway, androgen receptor (AR), and clinicopathological factors in hormone-naive prostate cancer. MATERIALS AND METHODS: This study was conducted with132 cases of hormone-naive prostate cancer treated by prostatectomy and prostate needle biopsy. An immunohistochemical study using antibodies against beta-catenin, matrix metalloproteinase-7 (MMP-7), and the AR was performed. For the in vitro study, PC-3, LNCaP, 22Rv1, and DU145 cell lines were used. RESULTS: The clinical or pathological stage ware a localized cancer in 36 patients (27.3%), locally advanced cancer in 31 (23.5%), and metastatic cancer in 65 (49.2%). We detected increased beta-catenin, AR, and MMP-7 expression with a high Gleason grade, disease progression, and increasing serum prostate-specific antigen (PSA) levels (p<0.01). In Spearman's rank correlations, the expression of cytoplasmic beta-catenin, MMP-7, and the AR were found to be significantly positively correlated. In addition, the expression of beta-catenin, MMP-7, and the AR were significantly correlated with clinicopathological variables indicative of a poor prognosis. Forty-nine patients with primary androgen deprivation had short response durations from hormone therapy to PSA progression with elevated MMP-7 expression on the Kaplan-Meier curve (p=0.0036). CONCLUSIONS: These data show that an activated Wnt/beta-catenin pathway and AR expression in prostate cancer are correlated with metastasis and aggressiveness. In addition, the expression of MMP-7 protein, a target of the Wnt/beta-catenin pathway, is associated with PSA progression in prostate cancer patients undergoing primary hormone therapy.
