A Case of Severe Skin Eruption Caused by Lamivudine in a Patient with Chronic Hepatitis B.
- Author:
Seok Bae KIM
1
;
Pyoung Ju SEO
;
Du San BAIK
;
Se Young YUN
;
Byung Ha KIM
;
Jung Eun SHIN
;
Hong Ja KIM
;
Il Han SONG
Author Information
1. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea. sm1213@paran.com
- Publication Type:English Abstract ; Case Report
- Keywords:
Hepatitis B;
Chronic;
Lamivudine;
Complication;
Skin eruption
- MeSH:
Aged;
Colon, Transverse;
Female;
Hernia, Abdominal/*diagnosis/radiography;
Humans;
Imaging, Three-Dimensional;
*Mesocolon;
Tomography, Spiral Computed
- From:The Korean Journal of Gastroenterology
2006;48(4):281-285
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Lamivudine is widely used for the treatment of chronic hepatitis B infection because of it's remarkable antiviral efficacy and safety. We report a case of severe skin eruption caused by lamivudine. A 47-year-old female was admitted because of jaundice and itching sensation. She was diagnosed as chronic hepatitis B infection a few years ago but did not receive any specific treatment. Laboratory data showed acute deterioration of chronic hepatitis B infection. We prescribed lamivudine as a rescue therapy. Her general condition improved and lab data showed improvement in liver function test thereafter. However, she complained of severe skin eruption and itching sensation a few days after the discharge. We stopped lamivudine because the symptoms did not improve despite the use of anti-histamine. Skin biopsy showed interface dermatitis. After stopping lamivudine, her symptoms improved. However, the skin eruption developed again after lamivudine was restarted. Adefovir was used instead, and the patient did not experience any further skin problems since then.
