Fractionated Stereotactic Radiation Therapy for Intracranial Benign Tumor: Preliminary Results of Clinical Application.
- Author:
Dae Yong KIM
1
;
Yong Chan AHN
;
Seung Jae HUH
;
Dong Rak CHOI
;
Jong Hyun KIM
;
Jung Il LEE
;
Kwan PARK
;
Do Hyun NAM
;
Moon Kyung KIM
Author Information
1. Department of Radiation Oncology, Samsung Medical Center, Syung Kyun Kwan University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Clinical Trial
- Keywords:
Fractionated stereotactic radiation therapy;
Relocatable head frame;
Intracranial tumor
- MeSH:
Adenoma;
Appointments and Schedules;
Cranial Nerves;
Craniopharyngioma;
Diagnosis;
Female;
Follow-Up Studies;
Head;
Humans;
Immobilization;
Male;
Meningioma;
Necrosis;
Neuroma, Acoustic;
Pituitary Neoplasms;
Radiotherapy;
Scalp;
Treatment Outcome
- From:The Journal of the Korean Society for Therapeutic Radiology and Oncology
1998;16(2):185-194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: With the development of stereotactic immobilization systems capable of reliable serial repositioning, fractionated stereotactic radiation therapy (FSRT) offers the potential for an improved treatment outcome by excellent dose delivery, and dose distribution characteristics with the favorable radiobiological properties of fractionated irradiation. We describe our initial experience using FSRT for the treatment of intracranial benign tumor. MATERIALS AND METHODS: Between August 1995 and December 1996, 15 patients (7 males and 8 females aged 6-70 years) were treated with FSRT. The patients had the following diagnosis : pituitary adenoma (10) including one patient who previously had received radiotherapy, craniopharyngioma (2), acoustic neurinoma (1), meningioma (2). Using the Gill-Thomas-Cosman relocatable head frame and multiple non-coplanar therapy, the daily dose of 2Gy was irradiated at 90% to 100% isodose surface of the isocenter. The collimator sizes ranged from 26mm to 70mm. RESULTS: In all patients except one follow-up lost, disease was well- controlled. Acute complication was negligible and no patient experienced cranial nerve neuropathies and radiation necrosis. In overall patient setup with scalp measurements, reproducibility was found to have mean of 1.1+/-0.6mm from the baseline reading. CONCLUSION: Relocatable stereotactic system for FSRT is highly reproducible and comfortable. Although the follow-up period was relatively short, FSRT is considered to be a safe and effective radiation technique as the treatment of intracranial tumor. But the fractionation schedule (fraction size, overall treatment time and total dose) still remains to be solved by further clinical trials.
