The effect of prostaglandin e1on the muscle flap in the rectus abdominis muscle of the rat.
- Author:
Ho Jik YANG
;
Ji Won JEONG
;
Young Jin SHIN
- Publication Type:Original Article
- MeSH:
Alprostadil;
Animals;
Blood Vessels;
Epigastric Arteries;
Hemodynamics;
Myocutaneous Flap;
Necrosis;
Prostaglandins;
Rats*;
Rectus Abdominis*;
Survival Rate;
Vasodilation
- From:Journal of the Korean Society of Plastic and Reconstructive Surgeons
1998;25(4):523-529
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Flap survival is critical to the success in reconstructive surgery, there have been many investigations to increase the blood supply to the flaps such as surgical delay and pharmacologic delay. Prostaglandin(PG) is released from various tissues including blood vessel in response to physical stimulus. Among the Prostaglandins, PGE1 has been proven to be a vasodilatation property and many authors have demonstrated its effect to increase blood supply after random cutaneous flap surgery. Clinically, however, muscle flap or musculocutaneous flap is more significantly used in reconstructive surgery and hemodynamic effects of PGE1 of this type of flap are still not documented. The authors designed the random muscle flap to study the hemodynamic effects of PGE1 of the muscle flap. Superior based rectus muscle flap was elevated from rats and the superior epigastric artery, its major vascular pedicle, was ligated to create the random-type muscle flap. Twenty two rats were divided into two experimental groups and each group had 11 rats; Group I: No drugs Group II: PGE1 injection group for 7 postoperative days intraperitoneally The average muscle flap survival rate of group I was 46+/-3.0 precent and it had a higher survival rate than the control group(23+/-4.3%). The muscle flap survival rates showed significant differences between the two groups (p< 0.005) This study shows that the administration of the PGE1, in clinical usage of the rare random muscle flap with a pedicle injury or musculocutaneous flap with the risk of distal cutaneous flap necrosis, such as TRAM flap, which might be much safer and popular.
