Clinical Usefulness of Human Immunodeficiency Virus(HIV)-1 p24 Antigen Testing.
- Author:
Kyou Sup HAN
1
;
Myoung Hee PARK
;
Yoo Sung HWANG
;
Yong Rae LEE
;
Sang In KIM
Author Information
1. Seoul National University College of Medicine.
- Publication Type:Original Article
- Keywords:
Transfusion-associated acquired immunodeficiency syndrome;
HIV-1 p24 antigen test
- MeSH:
Blood Donors;
Blotting, Western;
Canada;
Donor Selection;
Enzyme-Linked Immunosorbent Assay;
HIV Infections;
HIV-1;
Humans*;
Korea;
Mass Screening;
Tissue Donors;
Volunteers
- From:Korean Journal of Blood Transfusion
1997;8(2):149-155
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Recently some countries such as U.S.A. and Canada where human immunodeficiency virus(HIV) infection is rather prevalent, included HIV-1 p24 antigen test as a routine donor blood screening. This study was performed to evaluate the advantage of additional p24 antigen testing for the prevention of transfusion-associated AIDS infection in Korea. METHODS: Blood collected from 1726 volunteer blood donors, 16 HIV-positive patients, 39 sera from 4 commercial seroconversion panels, 15 sera included in low titer performance panel were tested with HIV-1 p24 Antigen ELISA Test System(Ortho Diagnostic Systems, U.S.A.). Anti-HIV antibody was also measured in parallel employing commercial kits produced by two world-famous companies. For some sera, western blot testing was additionally done. RESULTS: False-positive rate of p24 antigen testing was 0.06%. In 2 examples from 4 seroconversion panels, the p24 antigen test detected HIV infection 1-25 days and 11-47 days earlier than anti-HIV tests. CONCLUSION: Additional p24 antigen testing was found to have a potential to reduce transfusion-associated HIV infections. Including the p24 antigen testing as a routine donor screening should be considered if the number of transfusion-associated HIV infections continues to grow in Korea.
