Changes in biochemical bone markers during pregnancy and puerperium.
10.3346/jkms.2000.15.2.189
- Author:
Byung Koo YOON
1
;
Jeong Won LEE
;
Doo Seok CHOI
;
Cheong Rae ROH
;
Je Ho LEE
Author Information
1. Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. bkyoon@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Biological Markers;
Pregnancy;
Lactation;
Disorder, Calcium Metabolism;
Osteoporosis
- MeSH:
Adult;
Amino Acids/urine;
Analysis of Variance;
Biological Markers*;
Bone Resorption/physiopathology*;
Calcium/metabolism;
Female;
Human;
Lactation/physiology;
Osteocalcin/blood;
Osteoporosis/physiopathology*;
Pregnancy;
Pregnancy Complications/physiopathology*;
Puerperium/physiology*
- From:Journal of Korean Medical Science
2000;15(2):189-193
- CountryRepublic of Korea
- Language:English
-
Abstract:
To elucidate the changes in bone turnover during pregnancy and puerperium, we measured serially the levels of serum osteocalcin and urine deoxypyridinoline (Dpy) as markers of bone formation and bone resorption, respectively, in 22 healthy women with normal pregnancy. Nineteen non-pregnant women served as control. The Dpy levels increased significantly at 16 weeks of pregnancy and remained elevated thereafter. The levels of osteocalcin, however, were significantly decreased at 16 weeks of pregnancy and elevated later at 6 weeks postpartum. Bone turnover ratio (Dpy/osteocalcin) continued to rise during pregnancy, but returned to control levels 6 weeks after delivery. Dpy levels and bone turnover ratio during puerperium tended to be higher in 17 breast-feeding women than those of 5 exclusive bottle-feeders. In conclusion, bone resorption begins to increase from the second trimester of pregnancy and calcium release from bone tissue might play a major role in calcium homeostasis during the whole period of pregnancy as well as during lactation.
