A Case of Cowden Disease Associated with Lhermitte-Duclos Disease.
- Author:
Jin Sun LEE
1
;
Kang Moon LEE
;
U Im CHANG
;
Woo Chul CHUNG
;
Hyun Mi CHO
;
Sung Kyoung KIM
;
Eun Jung KIM
;
Kang Hyun CHOI
;
Sung Hoon JUNG
;
Hyun Joo CHOI
;
Jin Mo YANG
;
In Sik CHUNG
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. jmyang@vincent.cuk.ac.kr
- Publication Type:Case Report
- Keywords:
Cowden disease;
Lhermitte-Duclos disease
- MeSH:
Breast;
Extremities;
Ganglion Cysts;
Goiter;
Hamartoma;
Hamartoma Syndrome, Multiple*;
Humans;
Keratosis;
Korea;
Middle Aged;
Thyroid Gland
- From:Korean Journal of Gastrointestinal Endoscopy
2004;29(1):36-40
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cowden disease (CD), also known as 'multiple hamartoma syndrome', is a rare autosomal dominant disorder with a high risk of breast, thyroid, or genitourinary malignancies. Lhermitte-Duclos Disease (LDD) is believed to be a hamartomatous overgrowth of cerebellar ganglion cells and currently is considered to be a part of CD. However, the report of the association between LDD and CD has been very unusual. We have recently experienced a 53-year-old man with LDD who had acral keratosis of extremities, gastrointestinal polyposis, and multinodular goiter. To our knowledge, it is the second case of CD associated with LDD in Korea. We report it with a review of the literatures.
