Effects of decreased cerebral perfusion pressure on cerebral hemodynamics, brain cell membrane function and energy metabolism during the early phase of experimental Escherichia coli meningitis in the newborn piglet.
10.3346/jkms.2000.15.2.203
- Author:
Won Soon PARK
1
;
Yun Sil CHANG
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wspark@smc.samsung.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Meningitis, Bacterial;
Intracranial Pressure;
Regional Blood Flow;
Energy Metabolism;
Animals, Newborn;
Spectroscopy, Near Infrared
- MeSH:
Animal;
Animals, Newborn;
Blood Glucose/metabolism;
Cell Membrane/microbiology;
Cell Membrane/enzymology;
Cerebral Cortex/metabolism;
Cerebral Cortex/chemistry;
Cerebral Cortex/blood supply;
Cerebrovascular Circulation/physiology*;
Energy Metabolism/physiology*;
Escherichia coli Infections/physiopathology*;
Escherichia coli Infections/metabolism*;
Glucose/cerebrospinal fluid;
Glucose/analysis;
Intracranial Pressure;
Lactic Acid/cerebrospinal fluid;
Lactic Acid/blood;
Lactic Acid/analysis;
Lipid Peroxidation/physiology;
Meningitis, Bacterial/physiopathology*;
Meningitis, Bacterial/metabolism*;
Na(+)-K(+)-Exchanging ATPase/metabolism;
Spectroscopy, Near-Infrared;
Swine
- From:Journal of Korean Medical Science
2000;15(2):203-210
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this study, we tested the hypothesis that decreased cerebral perfusion pressure (CPP) induces cerebral ischemia and worsen brain damage in neonatal bacterial meningitis. Meningitis was induced by intracisternal injection of 10(9) colony forming units of Escherichia coli in 21 newborn piglets. Although CPP decreased significantly at 8 hr after bacterial inoculation, deduced hemoglobin (HbD), measured as an index of changes in cerebral blood flow by near infrared spectroscopy, did not decrease significantly. In correlation analyses, CPP showed significant positive correlation with brain ATP and inverse correlation with brain lactate levels. CPP also correlated positively with HbD and oxidized cytochrome aa3 (Cyt aa3) by near infrared spectroscopy. However, CPP did not show significant correlation with cerebral cortical cell membrane Na+,K+-ATPase activity, nor with levels of lipid peroxidation products. In summary, decreased CPP observed in this study failed to induce cerebral ischemia and further brain injury, indicating that cerebrovascular autoregulation is intact during the early phase of experimental neonatal bacterial meningitis.
