Feasibility of In vivo Proton Magnetic Resonance Spectroscopy for Lung Cancer.
10.13104/jksmrm.2012.16.1.40
- Author:
Soon Ho YOON
1
;
Chang Min PARK
;
Chang Hyun LEE
;
In Chan SONG
;
Hyun Ju LEE
;
Jin Mo GOO
Author Information
1. Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea. jmgoo@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Magnetic resonance;
Spectroscopy;
Lung cancer
- MeSH:
Choline;
Ethics Committees, Research;
Humans;
Informed Consent;
Lung;
Lung Neoplasms;
Magnetic Resonance Spectroscopy;
Magnetics;
Magnets;
Male;
Prospective Studies;
Protons;
Spectrum Analysis
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2012;16(1):40-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the feasibility of in vivo proton magnetic resonance spectroscopy (MRS) for evaluation of lung cancer. MATERIALS AND METHODS: This prospective study was approved by the institutional review board of our hospital and informed consent was obtained in all patients. Ten patients (7 men, 3 women; mean age, 64.4) with pathologicallyproven lung cancer (mean, 56.8 mm; range, 44-77 mm) were enrolled to 1.5 T MRS using a single-voxel respiration-triggered point-resolved spectroscopic sequence. Technical success rate and the reason of technical failure, if any, were investigated. RESULTS: Out of 10 lung cancers, analyzable MRS spectra were obtained in 8 tumors (technical success rate, 80%). Two MRS datasets were not able to be analyzed due to serious baseline distortion. Choline and lipid signals were detected as major metabolites in analyzable MRS spectra. CONCLUSION: In vivo proton MRS method using a single-voxel respiration-triggered point-resolved spectroscopic sequence is feasible in obtaining the MR spectra of lung cancer because these spectra were analyzable and high success rate was shown in our study although there was the limitation of small patient group.
