Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents.
10.4062/biomolther.2014.064
- Author:
Hye Jin CHA
1
;
Min Ji SONG
;
Kwang Wook LEE
;
Eun Jung KIM
;
Young Hoon KIM
;
Yunje LEE
;
Won Keun SEONG
;
Sa Ik HONG
;
Choon Gon JANG
;
Han Sang YOO
;
Ho Sang JEONG
Author Information
1. Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709, Republic of Korea. hosa33@korea.kr
- Publication Type:Original Article
- Keywords:
Tramadol;
Dopamine system;
Serotonin system;
Drug dependence;
Animal behavioral tests
- MeSH:
Animals;
Behavior, Animal;
Head;
Korea;
Pharmacology*;
Rodentia*;
Substance-Related Disorders;
Tramadol*
- From:Biomolecules & Therapeutics
2014;22(6):558-562
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.
