Evaluation of Osseointegration around Tibial Implants in Rats by Ibandronate-Treated Nanotubular Ti-32Nb-5Zr Alloy.
10.4062/biomolther.2014.111
- Author:
Manoj NEPAL
1
;
Liang LI
;
Tae Sung BAE
;
Byung Il KIM
;
Yunjo SOH
Author Information
1. Department of Dental Pharmacology, School of Dentistry, and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University, Jeon-Ju 561-756, Republic of Korea. ysoh@jbnu.ac.kr
- Publication Type:Original Article
- Keywords:
Dental implants;
Osseointegration;
Titanium alloy;
Ibandronate;
Nanotubes
- MeSH:
Alloys*;
Animals;
Dental Implants;
Dentistry;
Hot Temperature;
Nanostructures;
Nanotubes;
Orthopedics;
Osseointegration*;
Osteogenesis;
Rats*;
Tibia;
Titanium;
Torque;
X-Ray Microtomography
- From:Biomolecules & Therapeutics
2014;22(6):563-569
- CountryRepublic of Korea
- Language:English
-
Abstract:
Materials with differing surfaces have been developed for clinical implant therapy in dentistry and orthopedics. This study was designed to evaluate bone response to titanium alloy containing Ti-32Nb-5Zr with nanostructure, anodic oxidation, heat treatment, and ibandronate coating. Rats were randomly assigned to two groups for implantation of titanium alloy (untreated) as the control group and titanium alloy group coated with ibandronate as the experimental group. Then, the implants were inserted in both tibiae of the rats for four weeks. After implantation, bone implant interface, trabecular microstructure, mechanical fixation was evaluated by histology, micro-computed tomography (microCT) and the push-out test, respectively. We found that the anodized, heat-treated and ibandronate-coated titanium alloy triggered pronounced bone implant integration and early bone formation. Ibandronate-coated implants showed elevated values for removal torque and a higher level of BV/TV, trabecular thickness and separation upon analysis with microCT and mechanical testing. Similarly, higher bone contact and a larger percentage bone area were observed via histology compared to untreated alloy. Furthermore, well coating of ibandronate with alloy was observed by vitro releasing experiment. Our study provided evidences that the coating of bisphosphonate onto the anodized and heat-treated nanostructure of titanium alloy had a positive effect on implant fixation.
