The Heme Oxygenase-1 Genotype is a Risk Factor to Renal Impairment of IgA Nephropathy at Diagnosis, Which is a Strong Predictor of Mortality.
10.3346/jkms.2009.24.S1.S30
- Author:
Ho Jun CHIN
1
;
Hyun Jin CHO
;
Tae Woo LEE
;
Ki Young NA
;
Hyung Jin YOON
;
Dong Wan CHAE
;
Suhnggwon KIM
;
Un Sil JEON
;
Jun Young DO
;
Jong Won PARK
;
Kyung Woo YOON
;
Young Tai SHIN
;
Kang Wook LEE
;
Ki Ryang NA
;
Dae Ryong CHA
;
Young Sun KANG
Author Information
1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. mednep@snubh.org
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Heme Oxygenase;
Glomerulonephritis, IGA;
Renal Insufficiency
- MeSH:
Adult;
Disease Progression;
Female;
Gene Frequency;
Genotype;
Glomerular Filtration Rate;
Glomerulonephritis, IGA/*genetics/mortality/*pathology;
Heme Oxygenase-1/*genetics;
Humans;
Male;
Middle Aged;
Odds Ratio;
Polymorphism, Genetic;
Promoter Regions, Genetic;
Risk Factors
- From:Journal of Korean Medical Science
2009;24(Suppl 1):S30-S37
- CountryRepublic of Korea
- Language:English
-
Abstract:
The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.
