Lipid A as a Drug Target and Therapeutic Molecule.
10.4062/biomolther.2015.117
- Author:
Sang Hoon JOO
1
Author Information
1. Laboratory of Biochemistry, College of Pharmacy, Catholic University of Daegu, Gyeongbuk 38430, Republic of Korea. sjoo@cu.ac.kr
- Publication Type:Review
- Keywords:
Lipid A;
Endotoxin;
Drug target;
Antibacterial;
Adjuvant
- MeSH:
Biosynthetic Pathways;
Lipid A*
- From:Biomolecules & Therapeutics
2015;23(6):510-516
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.
