The Association of Abdominal Fat with Serum Insulin and Atherogenic Index for Obese Females.
- Author:
Ka Young LEE
1
;
Hae Sook SOHN
;
Nam Su LEE
;
Jung Hee HAN
;
Ki Jung KIM
Author Information
1. Department of Family Medicine, Inje University Medical School, Korea. Fmlky@ijnc.inje.ac.kr
- Publication Type:Original Article
- Keywords:
abdominal fat;
obesity;
women;
fasting insulin;
atherogenic index
- MeSH:
Abdominal Fat*;
Adipose Tissue;
Cholesterol;
Coronary Disease;
Fasting;
Female*;
Humans;
Insulin*;
Obesity;
Obesity, Abdominal;
Waist Circumference;
Waist-Hip Ratio
- From:Journal of the Korean Academy of Family Medicine
2002;23(7):917-924
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study was to find an independent relationship between waist circumference/waist-to-hip ratio which estimates abdominal fat and fasting insulin/atherogenic index which is a predictor of coronary heart disease in obese women. METHODS: The subjects were 80 obese (BMI > or = 25 kg/m2) women. Whole body fat was estimated by body fat mass, % body fat using bioelectrical impedence, and by BMI. Abdominal fat was measured by waist circumference (WC) and waist-to-hip ratio. Fasting insulin was examined and atherogenic index was defined asthe ratio of serum total cholesterol to HDL-cholesterol. Independent association between abdominal fat and insulin/AI was analyzed using partial correlation, multiple regression and Hotelling t-test. RESULTS: Among subjects, 85.7% of obese women had WC greater or equal to 80 cm. The mean BMI was 30.3 kg/m2. The partial correlations between whole body fat and insulin/AI were not significantly different from the partial correlations between abdominal fat and insulin/AI. When age and height were adjusted, partial correlations between abdominal fat and insulin were 0.38 and 0.39. The partial correlations were reduced to 0.15-0.29 after further adjusting for whole body fat. Age and height-adjusted partial correlations between abdominal fat and AI were 0.34 and 0.36. The partial correlations were reduced to 0.11-0.17 when whole body fat was additionally adjusted. Whole body fat explained 9.9-13.7% for variability of insulin; abdominal fat explained 14.2% and 15.9%. Whole body fat explained 12.5-12.8% for variability of AI and abdominal fat explained 11.9%. CONCLUSION: Most of the obese women showed abdominal obesity. Abdominal fat did not seem to be independently associated with fasting insulin and atherogenic index.
