Risk Factors Associated with Respiratory Virus Detection in Infants Younger than 90 Days of Age.
- Author:
Yeun Joo EEM
;
E Young BAE
;
Jung Hyun LEE
;
Dae Chul JEONG
- Publication Type:Original Article
- Keywords:
Infants;
Nasopharynx;
Virus disease;
Respiratory tract infections;
Real-time polymerase chain reaction
- MeSH:
Adenoviridae;
Bacterial Infections;
Bocavirus;
Communicable Diseases;
Coronavirus;
Cough;
Humans;
Infant*;
Logistic Models;
Metapneumovirus;
Nasopharynx;
Orthomyxoviridae;
Paramyxoviridae Infections;
Prevalence;
Real-Time Polymerase Chain Reaction;
Respiratory Syncytial Viruses;
Respiratory Tract Infections;
Retrospective Studies;
Rhinovirus;
Risk Factors*;
Seasons;
Sepsis;
Virus Diseases
- From:Korean Journal of Pediatric Infectious Diseases
2014;21(1):22-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study aimed at determining the detection rate of respiratory viruses and at investigating the risk factors associated with respiratory virus detection in young infants. METHODS: From September 2011 to August 2012, nasopharyngeal swabs were obtained from 227 infants aged < or =90 days with suspected infectious diseases, including sepsis. We performed a retrospective analysis of their clinical characteristics. The prevalence of respiratory viruses in their nasopharyngeal swabs was assayed by real-time polymerase chain reaction (real-time PCR). RESULTS: In total, 157 (69.2%) infants had more than one of the following respiratory viruses: respiratory syncytial virus (n=75), rhinovirus (n=42), influenza virus (n=18), parainfluenza virus (n=15), human metapneumovirus (n=9), coronavirus (n=9), adenovirus (n=4), and bocavirus (n=3). During the same period, bacterial infections were confirmed in 24 infants (10.6%). The detection of respiratory viruses was significantly associated with the presence of cough, a family history of respiratory illness, and a seasonal preference (fall/winter). Using logistic regression analysis, these 3 variables were also identified as significant risk factors. During fall and winter, detection of respiratory viruses was significantly higher in infants who did not have a bacterial infection. CONCLUSION: Respiratory virus is an important pathogen in young infants admitted to a hospital, who are suspected with infectious diseases. Detection of respiratory viruses in young infants was associated with seasonality (fall/winter), presence of respiratory symptoms and a family history of respiratory illness.
