Multiple Congenital Melanocytic Nevi Associated with Developmental Delay.
- Author:
Soon Hyo KWON
1
;
Sun Jae NA
;
Kkot Bora YEOM
;
Sun Young HUH
;
Jung Im NA
Author Information
1. Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. vividna@gmail.com
- Publication Type:Case Report
- Keywords:
Magnetic resonance imaging;
Multiple congenital melanocytic nevi;
Neurocutaneous melanosis;
Neurodevelopmental assessment;
Neurodevelopmental delay
- MeSH:
Brain;
Humans;
Infant;
Language Development Disorders;
Magnetic Resonance Imaging;
Melanoma;
Melanosis;
Neurocutaneous Syndromes;
Nevus, Pigmented;
Rare Diseases;
Seizures;
Seizures, Febrile
- From:Korean Journal of Dermatology
2011;49(8):753-756
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple congenital melanocytic nevi (MCMN), defined as the distribution of more than three small- or medium- sized congenital melanocytic nevi (CMN) on the body without a giant CMN, is a rare disease comprising about 4% of patients with CMN. Because MCMN accompanies neurodevelopmental delay, including seizures in 25% of patients as well as the risk of malignant melanoma, it must be carefully followed-up. We report a case of MCMN with developmental delay in a 19-month-old Korean boy. He had a history of febrile seizure when he was 18 months old. He showed a speech delay after the 1-year-follow up, even though there was no evidence of neurocutaneous melanosis (NCM) on brain magnetic resonance imaging (MRI) at the first visit. As MRI has a low sensitivity for detecting NCM in patients with MCMN older than 4-months, close neurodevelopmental assessments should be considered to provide a chance for early rehabilitation.
