In Vivo 31P Magnetic Resonance Spectroscopy in Liver Cirrhosis: Assessment of Phosphorus Metabolites accordingto Hepatic Dysfunction.
10.3348/jkrs.1998.39.6.1171
- Author:
Kwon Ha YOON
1
;
Moon Gyu LEE
;
Jung Hee LEE
;
Chang Guhn KIM
;
Yong Ho AUH
Author Information
1. Department of Diagnostic Radiology, Asan Medical Center, College of Medicine, University of Ulsan.
- Publication Type:Original Article
- Keywords:
Liver, cirrhosis;
Liver, MR;
Magnetic resonance (MR), spectroscopy
- MeSH:
Fibrosis;
Humans;
Liver Cirrhosis*;
Liver*;
Magnetic Resonance Spectroscopy*;
Phosphorus*
- From:Journal of the Korean Radiological Society
1998;39(6):1171-1176
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To assess the spectral alteration of phosphorus metabolities in patients with liver cirrhosis andcompare energy metabolites with clinical grades using 31P MR spectra localized by two-dimensional chemical shiftimaging. MATERIALS AND METHODS: In 15 normal (control) subjects and 12 patients with liver cirrhosis, 31P MRspectroscopy was undertaken. Patients were divided into two groups, namely 'mild cirrhosis' (Child A, n=5) and'severe cirrhosis' (Child B and C, n=7) according to disease severity, as assessed by Child-Hugh's classification.In vivo 31P MR spectroscopy was performed on a 1.5-T system (Magnetom Vision; Erlangen, Germany), using a surfacecoil. Peak areas of phosphomonoester (PME), inorganic phosphate (Pi), phosphodiester (PDE), and gamma-, alpha- andbeta-ATP were defined. Peak areas of phosphorous metabolites in the spectra were expressed as values of PME/beta-ATP,PDE/beta-ATP, PME/ATP, and PME/PDE. RESULTS: The values of PME/beta-ATP, PDE/beta-ATP, PME/ATP, and PME/PDE betweencontrol subjects and patients with liver cirrhosis were significantly different. With impaired hepaticdysfunction, PME increased as PDE decreased. In patients with severe cirrhosis, the values of PME/(-ATP andPME/ATP were significantly higher than those of patients with mild cirrhosis. CONCLUSION: In patients with livercirrhosis, peak areas of PME, were significantly higher, and this might reflect the severity of hepaticdysfunction. PME/(-ATP and PME/ATP valves appear predict the severity of cirrhosis.
